Fragility fractures of the femoral neck are among the leading causes of morbidity and mortality in osteoporosis in the elderly, carrying a high risk of contralateral fractures and placing a significant socio-economic burden on national health systems. Although pharmacological treatments are essential for improving bone mineral density (BMD, g/cm²), they require several months to significantly reduce fracture risk and are limited by low patient adherence. In this context, techniques such as the local osteo-enhancement procedure (LOEP) are emerging as promising strategies for the prevention of osteoporotic fractures, offering a more rapid therapeutic onset. LOEP with AGN1, a resorbable tri-phasic biomaterial based on calcium sulfate, brushite, and beta-TCP, represents an innovative alternative due to its ability to enhance the mechanical strength of bone and stimulate physiological bone regeneration. The material showed complete resorption within 24 weeks, leading to an average BMD (g/cm²) up to 68%. Unlike traditional techniques, LOEP with AGN1 does not interfere with potential subsequent surgical procedures and does not induce thermal necrosis, making it a promising therapeutic option for the prevention of fragility fractures of the proximal femur.
KEY WORDS: Osteoporosis, osteo-enhancement, local osteo-enhancement procedure, hip fractures, fracture prevention.
